PlayAround 3,500 people who were born with thalidomide-related defects at birth are seeking fresh compensation.
It comes 50 years after the drug was first given to pregnant women as a cure for morning sickness.
Around 10,000 babies were born with defects caused by the drug, ranging from malformed limbs to no arms or legs, and a first payout came in the 1970's.
However, those who are still living claim they are finding old age increasingly difficult and, under the name of the International Contergan Thalidomide Alliance (ICTA), are demanding at least £3 billion in compensation from both the German drug manufacturer Grunenthal and the German government.
ICTA campaign leader Nick Dobrik said compensation plans agreed in the 1970s were inadequate and no longer ensure victims are well cared for.
Settlements varied widely, with victims in Germany receiving only a fraction of their counterparts in Britain, and those in Italy and Spain getting no compensation at all.
But Grunenthal claimed the group was "actively and aggressively" attacking the company.
A spokesman for Germany's Ministry for Families, Seniors, Women and Youth said the government had recently taken steps to double the pensions of thalidomide victims, though it acknowledged that further measures would be necessary.
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