Sadio Mane scored a hat-trick and Mohamed Salah continued his phenomenal run with a 30th of the season as Liverpool won 5-0 at Porto to virtually assure themselves a Champions League quarter-final place.
Two late Real Madrid goals earned the reigning Champions League holders a 3-1 home victory over Paris St Germain in the first leg of their last-16 tie.
Christian Eriksen completed a remarkable Tottenham comeback as they rallied from two down to draw with Juventus in the Champions League last 16.
Ilkay Gundogan scored twice as Manchester City put one foot in the Champions League quarter-finals with an emphatic 4-0 win over Basel.
A scintillating display of football from Liverpool's 'Fab Four' saw Jurgen Klopp's side blaze their way into the Champions League knockout phase with a 7-0 victory over Spartak Moscow.
First-half goals from Brazilian pair Bernard and Ismaily stunned Pep Guardiola's side on a freezing night at the Metalist Stadium in Kharkiv, with Sergio Aguero's injury-time penalty too late to affect the outcome.
Fernando Llorente and Georges-Kevin Nkoudou scored their first goals for Tottenham goal as Spurs strolled into the Champions League last 16 by beating Apoel Nicosia.