The match gets underway with Chelsea hoping to make an early breakthrough.
Manchester City surrendered a two-goal lead as they again stuttered on the Champions League stage, drawing 2-2 amid more controversy at CSKA Moscow.
Arsenal manager Arsene Wenger has every confidence rookie goalkeeper Emiliano Martinez will be up to the challenge of his Champions League debut away to Anderlecht on Wednesday night.
Liverpool face Real Madrid in the Champions League for the first time since the Reds' 4-0 victory at Anfield in 2009. Here, Press Association Sport looks at the players who are likely to have an impact.
Liverpool manager Brendan Rodgers has a decision to make over striker Mario Balotelli for the visit of European champions Real Madrid.
Gareth Bale will be a notable absentee from the mouthwatering clash between Real Madrid and Liverpool, but Reds manager Brendan Rodgers admits the presence of Cristiano Ronaldo means that may be of little advantage to his side.