Borussia Dortmund came from two goals down to secure a 2-2 draw with Real Madrid and win Group F in the Champions League.
Lucas Perez scored a hat-trick as Arsenal, who had already qualified for the last 16, secured top spot in Group A with a 4-1 victory in Basle.
Leicester marched into the last 16 of the Champions League with victory over Club Brugge but Tottenham were eliminated following defeat in Monaco.
Premier League champions Leicester, who have struggled in the defence of their domestic title, have saved their best form for Europe this season and the unbeaten Foxes secured their progression with a fourth win in five Group G matches thanks to goals from Shinji Okazaki and Riyad Mahrez.
Tottenham's Wembley curse struck again as Mauricio Pochettino's men slipped to a 1-0 defeat against Bayer Leverkusen in the Champions League.
Leicester missed the chance to seal qualification to the knockout stages of the Champions League after a forgettable 0-0 draw in Copenhagen.
Ilkay Gundogan scored twice as Manchester City recorded a famous Champions League victory over manager Pep Guardiola's former side Barcelona.