Lionel Messi became the record Champions League goalscorer and Luis Suarez opened his account for Barcelona as the Catalan giants cruised to a 4-0 win over APOEL Nicosia.
Mikel San Jose kept Athletic Bilbao's European hopes alive by ending Shakhtar Donetsk's hopes of topping Champions League Group H.
Sergio Aguero struck twice in the closing minutes to complete a hat-trick and revive Manchester City's Champions League hopes with a 3-2 win over 10-man Bayern Munich.
Paris St Germain maintained their edge over Barcelona at the top of Champions League Group F with a comfortable 3-1 win over Ajax at the Parc des Princes.
Roberto Di Matteo played down the talk of a revenge mission as Chelsea visited Gelsenkirchen to take on his Schalke side - but it was embarrassment that greeted the Italian as the Blues eased into the knockout stages of the Champions League.
The referee blows for full time and City have a famous victory. They took an early lead and then collapsed to trail 2-1 to a 10-man Bayern. They have Aguero to thank for the dramatic late comeback, just as they have in the past.