It has been a miserable return to Europe's elite after a five-year absence for Liverpool and here we look at some of the areas where it has gone wrong.
Arsene Wenger got the "strong response" he was looking for in Turkey as Arsenal put the criticism of recent days behind them with some "good penetration" in Turkey.
Cristiano Ronaldo became Real Madrid's leading Champions League goalscorer, following his exploits against Ludogorets.
You can watch every goal right here.
Edin Dzeko believes he can rise to the big occasion when Manchester City's immediate Champions League fate is determined in Rome.
City face Roma at a fevered Stadio Olimpico on Wednesday hoping for the result that can prolong their latest campaign in Europe's elite competition.
A goalless draw with Atletico Madrid in Turin was enough to secure Juventus their progression to the last 16 of the Champions League.
The Italians enjoyed the better chances of a largely uneventful Group A encounter with last year's finalists, with Arturo Vidal and Paul Pogba both going close to scoring in the second half.
Liverpool manager Brendan Rodgers told ITV Sport he was not happy with the referee's decision to dismiss Lazar Markovic for a flailing arm.
The Northern Irishman also stated his hope that the draw would not be captain Steven Gerrard's last Champions League game in a Liverpool shirt.
Cristiano Ronaldo surpassed Raul's Champions League goals haul as Real Madrid thumped Ludogorets 4-0 to complete a flawless Group B campaign.
Ronaldo notched his 72nd Champions League strike to overtake Real stalwart Raul's previous competition record, recently eclipsed by Barcelona forward Lionel Messi.