Liverpool come up against Besiktas, Everton will play Young Boys, Spurs face Fiorentina and Celtic have been drawn against Inter Milan in the Europa League last 32.
Arsenal have been drawn against Monaco, Chelsea will play Chelsea in a repeat of last year's quarter-final and Man City face Barcelona in the Champions League last 16.
Tottenham boss Mauricio Pochettino says he would relish a Europa League meeting with the club's former manager Andre Villas-Boas.
Already-qualified Celtic concluded their Europa League Group D campaign with a 4-3 defeat to Dinamo Zagreb in a free-scoring encounter at the Stadion Maksimir.
A far from full-strength Hoops side fell behind to Marko Pjaca's strike after 14 minutes before goals from Kris Commons and Stefan Scepovic had the visitors ahead.
Everton's young side were unable to maintain the club's unbeaten European record this season as Krasnodar chalked up a 1-0 victory at Goodison Park.
Kone rises highest to get on the end of a Luke Garbutt free-kick, but he flashes the header over.