Police have confirmed there are a "number of fatalities" after a bin lorry careered out of control hitting pedestrians in Glasgow city centre today.
A last day of crunch negotiations to secure a new political deal in Northern Ireland are set to go "down to the wire", Stormont's First Minister has said.
Democratic Unionist leader Peter Robinson struck an optimistic note, saying there was a "real chance" of an agreement.
Eyewitness David Lyon, 26, told ITV News that he was crossing the road with his girlfriend when saw the bin truck involved in today's fatal collision in Glasgow city centre "ploughing through the crowds".
He described hearing "large explosions...bangs," followed by screams.
The scene was "chaos," he said.
The Northern Ireland Secretary has warned today could be a "very long day" as talks aimed at resolving budgetary and other issues approach their deadline.
The region's politicians have agreed a potential way forward on finances, but there is not yet consensus on issues such as flying flags, parades, the legacy of the past and the structures of the Stormont executive.
"It could be a very long day but I think it is very important that we all seek to grasp this opportunity," she said.
She insisted the financial package on offer from Westminster was "generous" but also bore in mind the UK's difficult fiscal situation.
Northern Ireland's leaders face a "deal or no deal" ultimatum on what the Government has warned is the final day of negotiations on outstanding disputes.
Talks to find consensus will end at midnight, with or without agreement, Northern Ireland Secretary Theresa Villiers has warned.
She said the Government had made a "positive and generous" financial offer to Northern Ireland's Executive, but the package is conditional on a wide-ranging agreement on a number of issues.
The Northern Irish political parties have asked Westminster for £2 billion of extra funding and loan access over the next ten years.
The Prime Minister has been examining the proposals over the last few days and Ms Villiers presented his response today.
Police Scotland has confirmed that the casualties of today's bin lorry crash in George Square, Glasgow have been taken to three hospitals; the Southern General Hospital, Glasgow Royal Infirmary and the Western Infirmary.
Glasgow-born Jim Murphy, the leader of the Scottish Labour Party, tweeted that his "thoughts and prayers" are with everyone injured in today's bin lorry crash in Glasgow.
Gordon Matheson, leader of Glasgow City Council, described today's fatal collision in the heart of the city centre as a "terrible tragedy" and said that the council's priority is now to assist emergency services.
This map shows the distance the lorry is thought to have travelled after losing control.
Superintendent Stewart Carle of Police Scotland told reporters at the scene that the lorry had hit several pedestrians as it careered along the road.
"I can't confirm how many fatalities there have been because it is over a number of sites."
Prime Minister David Cameron has tweeted he is being kept fully briefed on the major incident in Glasgow.
A dedicated phone line has been set up following the bin lorry crash in Glasgow's George Square today.