A gunman in a gas mask and body armour killed 12 people at a midnight premiere of the new Batman film in Denver, US.
The attack - which injured 59 others including children - started when the suspect hurled a gas canister into the room and then opened fire on the audience.
James Eagan Holmes, 24, who dropped out from studying neurosciences at the University of Colorado last month, was named by police as the suspect. Aurora police said they are "confident" he acted alone.
Holmes's family issued a statement of sympathy for the victims and asked for privacy while they "process this information."
The suspect also booby trapped his Aurora apartment which was crisscrossed with trip wires connected to what appeared to be plastic bottles containing an unknown liquid.
Officers took the suspect - who was armed with a high-powered rifle, a shotgun and two pistols - into custody in the car park behind the cinema, he surrendered without a fight police said.
Eyewitnesses said the gunman appeared at the front of the cinema during the film and released a canister which let out a hissing noise before gunfire erupted.
Confusion reigned as the shooting broke out, with one person in the cinema saying he thought it was a "stunt".
President Barack Obama urged Americans to "stand together" with the people of Aurora and said political campaigning ahead of the November 6 election should be put aside, during a previously scheduled campaign event in Florida.
White House officials saw no connection to terrorism, an Obama spokesman said.
Obama's opponent, Republican presidential candidate Mitt Romney said he was "deeply saddened" by the events and pulled all political television adverts in Colorado until further notice.
The shooting evoked memories of the 1999 massacre at Columbine High School - which is only 17 miles away from Aurora - where two students opened fire and killed 12 students and a teacher.
In New York, police will deploy officers at screenings of The Dark Knight Rises throughout the city "as a precaution against copycats," Police Commissioner Raymond Kelly said in a statement.
Jessica Zacholl, a spokeswoman for Time Warner-owned Warner Bros., the studio behind the film, said: