Jeremy Hunt and Chris Grayling have been among the key movers as David Cameron courted minor controversy in reordering the middle-ranking roles in his Cabinet for the first time.
Former employment minister Grayling replaced Ken Clarke at the Justice Department - a move that will have displeased the Liberal Democrats in the Coalition while delighting the Tory right.
Westminster veteran Clarke will remain in the Cabinet, advising on a range of issues as a minister without portfolio.Political Editor Tom Brady reports:
Former culture secretary Hunt has replaced Andrew Lansley as Health Secretary, regarded as one of the Government's most difficult current briefings.
After a difficult stint at the Health Department, Lansley has replaced the departing Sir George Young as Leader of the House of Commons.
Mr Cameron controversially removed Justine Greening from her role as Transport Secretary, a move immediately condemned by London Mayor Boris Johnson for apparently softening the Government's objections to a third runway at Heathrow Airport.
Ms Greening was named International Development Secretary in the reshuffle, with Patrick McLoughlin replacing her at the Transport Department.
Maria Miller has joined the Cabinet as Mr Hunt's replacement as Culture Secretary. She will also serve as Minister for Women And Equalities, a role previously occupied by Home Secretary Theresa May.
Mr McLoughlin was free to inherit his role after former UN peacekeeper Andrew Mitchell took his previous role as the chief whip - the key enforcer role for a Tory party that has become increasingly rebellious.
The Prime Minister made the appointment first to allow Mr Mitchell to be involved in the discussions about the rest of the shake-up, which is the first to be partially announced through social media.
Baroness Warsi and Cheryl Gillan both used their Twitter accounts to confirm their departures as Tory Chairman and Welsh Secretary, respectively.
Baroness Warsi, though, will still attend Cabinet after being named Senior Foreign Office Minister.
Welsh speaker David Jones was named as Gillan's replacement as Secretary of State for Wales.
Former Northern Ireland secretary Owen Paterson, meanwhile, was named Environment Secretary in the Cabinet reshuffle, replacing the outgoing Caroline Spelman.
Former transport minister Theresa Villiers inherited his Northern Ireland brief.
Here is the full list of Cabinet movers in their new roles:
- Jeremy Hunt, Health Secretary
- Chris Grayling, Justice Secretary
- Andrew Lansley, Leader of the House of Commons
- Justine Greening, International Development Secretary
- Patrick McLoughlin, Transport Secretary
- Andew Mitchell, Chief Whip
- Maria Miller, Culture Secretary and Minister for Women And Equalities
- Owen Paterson, Environment Secretary
- Theresa Villiers, Northern Ireland Secretary
- David Jones, Welsh Secretary
- Baroness Warsi, Senior Foreign Office Minister
- David Laws, Education Minister
- Ken Clarke, Minister without portfolio
- Grant Shapps, Minister without portfolio, Tory Party chairman
- Oliver Heald, Solicitor General
Yet the vast majority of the "big hitters" in the Cabinet remained unchanged. Alongside the Prime Minister, the following ministers were unaffected by the reassignments:
- Nick Clegg, Deputy Prime Minister
- George Osborne, Chancellor of the Exchequer
- William Hague, Foreign Secretary
- Theresa May, Home Secretary
- Vince Cable, Business Secretary
- Iain Duncan Smith, Work and Pensions Secretary
- Michael Gove, Education Secretary
- Danny Alexander, Chief Secretary to the Treasury
- Ed Davey, Energy Secretary
- Michael Moore, Scotland Secretary