Jonnie Peacock, the 19-year-old amputee sprinter and T44 100m world record holder will bid for victory ahead of defending champion Oscar Pistorius, the Blade Runner, and world champion Jerome Singleton in one of the most hotly anticipated events of the Games.
Peacock, from Cambridge, is the fastest Paralympian in the world and set a blistering pace through his heat last night - setting up a tantalising final tonight.
David Weir, 33, is looking to make it into the triple crown club as he goes for gold in tonight's 800m final. He will also take part in Sunday's marathon on London's streets, and is favourite to make it a clean sweep of quadruple gold.
Discus world champion Daniel Greaves will start as favourite for gold but will expect tough competition from Jeremy Campbell of the USA who broke Greaves' world record back in June. Greaves won bronze in Beijing, gold in Athens and silver in Sydney.
Hannah Cockroft - who calls her wheelchair Sally - will be lining up to win her second gold as she races in the 200m tonight. The 20-year-old, from Halifax, smashed the Paralympic record on her way to her previous win and will be hoping for a similar performance later.
One more gold medal today in the women’s road race will see Sarah Storey equal the modern-day record of Paralympic legends Baroness Tanni Grey-Thompson and Dave Roberts.
Helena Lucas will be going for gold on the final day of the sailing competition in Weymouth.
Jonathan Fox holds the world record in the S7 400m freestyle. Steph Millward goes in the 200m medley.