Women smokers can earn themselves 10 years of extra life by quitting the habit before middle age, say scientists.
A study of 1.3 million women found that smoking tripled the chances of dying over nine years compared with non-smokers.
Most of the increased death rate resulted from smoking-related diseases such as lung cancer, chronic lung disease, heart disease or stroke.
The risk rose steeply with the quantity of tobacco smoked, but even light smokers who puffed fewer than 10 cigarettes a day doubled their likelihood of dying.
Smokers who kicked the habit around age 30 avoided 97% of their excess risk of premature death.
The authors of the Million Women Study wrote in The Lancet medical journal: "Smokers lose at least 10 years of lifespan. Although the hazards of smoking until age 40 years and then stopping are substantial, the hazards of continuing are 10 times greater".
Women aged 50 to 65 were enrolled into the study, designed to investigate links between health and lifestyle, from 1996 to 2001.
Participants completed a questionnaire about living habits, medical and social factors and were re-surveyed three years later. Women were monitored for a total of 12 years on average, during which there were 66,000 deaths.
Initially, 20% of the women were smokers, 28% were ex-smokers, and 52% had never smoked.
Those who still smoked at the three year re-survey were almost three times more likely than non-smokers to die over the next nine years.
Both the hazards of smoking and the benefits of quitting were greater than previous studies had suggested, said the researchers.
In a linked comment, Professor Rachel Huxley, from the University of Minnesota, US, said: "In most of Europe and the USA, the popularity of smoking among young women reached its peak in the 1960s, decades later than for men. Hence, previous studies have underestimated the full eventual impact of smoking on mortality in women, simply because of the lengthy time lag between smoking uptake by young women and disease onset in middle and old age".