Two senior BBC figures have "stepped aside" as a result of a botched Newsnight investigation which also contributed to the resignation of director general George Entwistle.
The BBC's director of news, Helen Boaden, and her deputy, Stephen Mitchell, have left their roles pending the findings of Nick Pollard's independent review.
Former Sky News boss Mr Pollard is looking into the decision-making process behind a dropped Newsnight report last year which would have examined sexual abuse allegations against Jimmy Savile.
ITV News correspondent Neil Connery reports:
Warning: This video contains flash photography.
The BBC's head of newsgathering, Fran Unsworth, and Ceri Thomas, the editor of the Radio 4 Today programme, will temporarily fill in for Ms Boaden and Mr Mitchell.
A BBC statement also confirmed that Karen O'Connor - a former deputy editor of Panorama and Newsnight - has also been drafted in as acting editor of Newsnight.
Iain Overton, the editor of the Bureau of Investigative Journalism, confirmed he had resigned from his position in the wake of its involvement in the Newsnight programme which broadcast allegations linking a senior Tory to child abuse.
Mr Overton had tweeted before the start of the programme that Newsnight would feature an item, which the BIJ worked on, about a "senior political figure" who is a paedophile.
Although the programme did not name the politician, it led to speculation on the internet.
Mr Overton today tweeted:
Tackling the crisis that has engulfed the BBC is the first priority for acting director general Tim Davie.
Mr Davie will set out his plans today for rebuilding trust in the corporation and held his first meeting with the BBC Trust last night.
His efforts to move on are likely to be hampered by a row over the disclosure that Mr Entwistle - who served only 54 days in the role - will receive a full year's salary of £450,000 in lieu of notice.
Culture Secretary Maria Miller said it was "tough to justify" the director general's pay-off.
The director general will also reportedly receive his full pension of £877,000, leading to a total payment of £1.32 million, according to The Telegraph.
The financial package was greeted with outrage by MPs with the chairman of the Commons Culture, Media and Sport Committee, John Whittingdale, questioning how the corporation could justify the pay-off.
Chairman of the BBC Trust Lord Patten earlier told ITV News the corporation must undergo a radical overhaul and "get a grip" on its journalism following the resignation of its Director-General amid the Newsnight scandals.
Lord Patten defended the appointment of Mr Entwistle and his own role in the crisis, including his inaction to the notorious tweet promoting Newsnight's - later unfounded - claims against a senior Tory peer.
Watch the full interview by ITV News's UK Editor Lucy Manning:
Downing Street appears willing to give the BBC a chance to get its own house in order in the wake of the crisis triggered by the disclosures of the Savile abuse, with Number 10 sources saying ministers would not be "jumping in" to intervene.
Labour has requested an urgent question on the BBC crisis in the House of Commons this afternoon.