Following allegations in a new book that the rescue pet was little more than a public relations prop, a "savelarry" hashtag quickly took off on Twitter.
Downing Street moved to dismiss suggestions in Matthew d'Ancona's In It Together that the cat was unloved.
Larry was re-homed at Number 10 on February 15 2011 by animal charity Battersea Dogs And Cats Home.
But the cat's initially lackadaisical approach to his mousing duties led to speculation that his days at No 10 could be numbered.
In August last year Downing Street confirmed the six-year-old feline had finally recorded a kill.