Pope Francis has said that the Mafia will "go to hell" if they do not repent and renounce their "blood-stained money and blood-stained power."
He made the comments at a prayer vigil for relatives of innocent victims killed by the Mafia.
Among the names of 842 victims read aloud was three-year-old Nicola “Coco” Campolongo.
Last week, he was shot in the head along with his grandfather, 52-year-old Giuseppe Iannicelli.
Two-year-old Domenico Petruzzelli was also killed along with his mother and her companion in a mob hit.
The pontiff was strong to denounce these actions:
The former head of the anti-mafia unit, Gian Carlo Caselli, said there could be repercussions from the underworld to the Pope's speech:
This was Pope Francis' first major address to Italian victims of organised crime. He told the mobsters: "You had a father, a mother. Think of them. Weep a little. And convert yourselves."
ITV News Europe Correspondent Emma Murphy reports: