The Scottish tennis star bought Cromlix, three miles from his home town of Dunblane, central Scotland, in February last year.
The Victorian mansion has been "extensively" refurbished and tourism chiefs believe the revamped hotel will prove to be a big draw for visitors from all over the world.
In a statement on the hotel's website, Murray said: "By re establishing Cromlix as a leading luxury hotel at the heart of the Dunblane community we will be able to attract new visitors to the area, create a number of new jobs and focus on supporting other local businesses. I'm pleased to be able to give something back to the community I grew up in."
The 15-bedroom hotel has been renovated to show-off much of the building's original heritage, including its own private chapel and loch.
The accommodation features 10 bedrooms and five suites which overlook manicured grounds and tennis courts.
It also boasts a restaurant called Chez Roux, overseen by legendary French chef Albert Roux and run by executive head chef Darin Campbell.