Video report by ITV News North of England correspondent Damon Green
Celebrations are being held across the country as the Queen becomes Britain's longest reigning monarch.
She overtakes Queen Victoria's record having held the crown for 64 years.
To mark the milestone, ITV News has spoken to people who have come to know Her Majesty in a very personal way.
Eleven-year-old Amy Carmichael, who had cancer for three years, met the Queen earlier this year during Her Majesty's visit to The Royal Hospital for Children in Glasgow.
Phil Bettington fought back "butterflies" when he met the Queen in his former role as the Mayor of Ledbury.
Lord William Wallace sung at the Queen's coronation at the age of 12 and met Her Majesty years later in his role as a privy counsellor.