Edgar Mitchell, who was the sixth man to walk on the moon, has died at the age of 85, his family said in a statement.
Mitchell was part of the Apollo 14 mission which lifted off on January 31st, 1971.
In a statement released by the Astronaut Scholarship Foundation, his family said he was "a man of extraordinary talents who never tired of encouraging others to strive and explore".
Buzz Aldrin, the second man on the moon, posted about Mitchell's death on Twitter.
In a statement NASA administrator Charles Bolden said: "As a member of the Apollo 14 crew, Edgar is one of only 12 men to walk on the moon and he helped to change how we view our place in the universe."
Mitchell was selected as a NASA astronaut in April 1966 after graduating first in his class from the Air Force Aerospace Research Pilot School, where he was both a student and an instructor.
When asked about his time in space he said: "You develop an instant global consciousness, a people orientation, an intense dissatisfaction with the state of the world, and a compulsion to do something about it."
He was inducted into the US Astronaut Hall of Fame on October 4th, 1997.