Lloyds Bank is to axe hundreds of jobs and close 21 branches during July 2016.
The cuts are part of the bank's Group Strategic Review outlined in 2014, in which it announced 200 branch closures over three years.
Officials from Unite Union say 625 jobs will be lost in total, affecting divisions including consumer finance, commercial banking and legal.
The union says the cuts will hit offices in London, Brighton, Gloucester, Leeds, Halifax and Wolverhampton.
Unite also says around 90 IT jobs will be moved offshore to India.
Lloyds says 195 new jobs will created as part of the Group Strategic Review, meaning the net loss of jobs will be 430.