A woman has been awarded more than $70 million (£58 million) for alleging that years of using Johnson & Johnson's baby powder caused her cancer.
The case is the latest lawsuit involving talcum powder's link with cancer, as concerns increase about the ramifications on health that extended talc use could have.
Johnson & Johnson said they will appeal the decision and insist that science proves their product is safe.
Californian Deborah Giannecchini was diagnosed with ovarian cancer in 2012. The suit accused Johnson & Johnson of "negligent conduct" in making and marketing its baby powder.
Earlier this year, two lawsuits in the United States ended in jury verdicts worth a combined $127 million (£105 million).
But two other lawsuits were thrown out by a New Jersey judge who said there wasn't reliable evidence that talc leads to ovarian cancer.
A statement from Carol Goodrich, spokesperson for Johnson & Johnson said: “We deeply sympathize with the women and families impacted by ovarian cancer.
"We will appeal today’s verdict because we are guided by the science, which supports the safety of Johnson’s Baby Powder.
"In fact, two cases pending in New Jersey were dismissed in September 2016 by a state court judge who ruled that plaintiffs’ scientific experts could not adequately support their theories that talcum powder causes ovarian cancer, a decision that highlights the lack of credible scientific evidence behind plaintiffs’ allegations.”