More than 150,000 Europeans could be killed every year by heatwaves by 2100, scientists predict.
Combined with wildfires, storms and floods, 152,000 people across the continent could die each year in weather-related events by the end of the century, unless reductions in greenhouse gas emissions are made and protections are put in place against extreme weather events, experts have warned.
By 2100, weather-related disasters could affect two-thirds of the continent's population, a forecast published in the journal The Lancet Planetary Health believes.
Between 1981 and 2010, an average of 3,000 people were killed each year in weather-related events, yet according to the research, this could increase 50 times, soaring to an average of 152,000 between 2071 and 2100.
The study analysed the probable impact of the seven most dangerous types of weather-related event - heatwaves, cold snaps, wildfires, droughts, river and coastal floods, and wind storms in the 28 European Union countries together with Switzerland, Norway and Iceland.
Rates of exposure to such disasters were projected to increase from one in 20 of the population at the start of the century to two in three people near its end.
Lead scientist Dr Giovanni Forzieri, from the European Commission's Joint Research Centre in Italy, said: "Climate change is one of the biggest global threats to human health of the 21st century, and its peril to society will be increasingly connected to weather-driven hazards.
"Unless global warming is curbed as a matter of urgency and appropriate measures are taken, about 350 million Europeans could be exposed to harmful climate extremes on an annual basis by the end of the century."
The team analysed 2,300 weather disaster records from 1981 to 2010 to estimate the vulnerability of people living in different countries to each of the seven kinds of event.
This information was then combined with climate change predictions and estimates of how populations might increase and migrate.
Heatwaves were found to be the most lethal weather effect, predicted to be responsible for 99% of future deaths. The number of people dying each year from excessive heat was expected to rise from 2,700 to 151,000.
The death toll from coastal flooding was also expected to rise substantially, from six deaths per year at the start of the century to 233 by 2100.
Wild fires, river floods, wind storms and droughts had less of an overall effect, but their impact could be concentrated in certain countries, said the researchers.
While global warming might see a reduction in deaths caused by very cold weather, this would not alter the general trend.
Southern Europe was likely to be hardest hit by weather disasters, mainly due to the heatwaves and droughts, according to the study. Here, weather events at the end of the century were projected to cause around 700 deaths per million people.
Northern European countries, such as the UK, were in much safer territory with an expected three weather-related deaths per million of the population.
Climate change accounted for 90% of the increased risk from weather disasters, with population growth, migration and urbanisation responsible for 10%, the research showed.
Dr Forzieri added: "This study contributes to the ongoing debate about the need to urgently curb climate change and minimise its consequences.
"The substantial projected rise in risk of weather-related hazards to human beings due to global warming, population growth, and urbanisation highlights the need for stringent climate mitigation policies and adaptation and risk reduction measures to minimise the future effect of weather-related extremes on human lives."
Paul Wilkinson, Professor of Environmental Epidemiology at the London School of Hygiene and Tropical Medicine, said: "While the analysis only considered extreme events, and assumed no reduction in human vulnerability over time from adaptation, it is yet another reminder of the exposures to extreme weather and possible human impacts that might occur if emissions of greenhouse gases continue unabated.
"It adds further weight to the powerful argument for accelerating mitigation actions to protect population health."