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David Cameron has said that if he sees that coalition is not working the party would "have to "face the new circumstances".
The Prime Minster also conceded that "sometimes... disagreements mean you can't take actions in the areas you want to".
– Prime Minister David Cameron
I'm here to deliver good government for the country, and we've still got important work to do - paying down the deficit, turning round the economy, and all the rest of it.
What matters to me, though, is can we get things done? Can we improve the state of the country? Can we fulfil our manifesto? The best way to do that is to continue with the coalition, but if that wasn't the case then we'd have to face the new circumstances in whatever way we should.
He added that he still believes the coalition has delivered "radical" changes for the country.
David Cameron has hinted that he could attempt to govern without the Liberal Democrats if disputes within the coalition made it impossible to continue.
The Prime Minister said that if difficulties between his Conservatives and Nick Clegg's Lib Dems meant the Government could not get things done "we'd have to face the new circumstances in whatever way we should".
The comments came as the Tory leadership attempted to defuse rows over claims that a senior figure called grassroots activists "swivel-eyed loons", plans to allow gay marriages and the party's policy on Europe.
In an interview with Total Politics magazine, Mr Cameron said: "The coalition has its frustrations, there's no doubt about it, and we have disagreements."
It will turn increasingly cloudy and damp in the east of UK, but will clear tomorrow morning. ITV Weather Presenter Lucy Verasamy has the details.
Britain must share the blame for the murder of a senior politician in Pakistan, former cricketer turned party leader Imran Khan has said.
Mr Khan has said a rival party leader, who lives in exile in England, is behind the killing of Zara Shahid Hussain, and that the UK government should have listened to the warnings.
ITV News Correspondent Martha Fairlie reports:
Nottinghamshire Fire and Rescue Service said appliances from Tuxford, Newark, Southwell and Collingham has attended to a suspected gas blast that ripped through a house in the area.
Coronation Street has picked up the coveted Best Soap award at the British Soap Awards.
The soap wrote on its Twitter page: "A huge thank you to everyone who voted in the British Soap Awards 2013".
Nottinghamshire Fire and Rescue Service area manager Craig Parkin has said that two children are among the casualties rescued with serious injuries, after a suspected gas blast ripped through a house in Newark.
Two people are still thought to be trapped in the rubble.
A local resident has told reporters that he and four other people helped to drag a man out of a wrecked property, after a suspected gas blast ripped through a house in Newark in Nottinghamshire.
Audie Cashie, who was informed that man's father was in the cellar of the house, said he was then ordered to leave the area by fire crews.
At least one person is still trapped and four people have been taken to hospital following a gas explosion at a house in Newark, Nottinghamshire Fire and Rescue said tonight.