Headliners include Elbow and Paul Weller, as well as the classical superstar Lang Lang who is to play his first outdoor festival.
The Chinese-born concert pianist has played sell-out performances around the world and recently played for President Obama at the White House.
Other stars on the bill are Bon Iver and Wild Beasts and The Horrors.
Musicians to feature include Bat For Lashes, Metronomy, Laura Marling, Richard Hawley and Janelle Monae, along with veterans such as Simple Minds, Daryl Hall and Thomas Dolby.
Latitude 2012 - which takes place from July 12 to 15 at Southwold- will also feature comedians Jack Dee, Tim Minchin and Reginald D Hunters.
Brian Cox is on the bill as he brings his Radio 4 show The Infinite Monkey Cage to a festival for the first time.