Nine people have been taken to hospital following a major accident on the A11, close to the Great War Memorial near Elveden.
A coach carrying 48 passengers, the majority of whom are teenagers and a black Mercedes were in collision on the A11 between the A1101 and the B1106 by the war memorial.
The coach was believed to have been a group of Ilford schoolchildren on a trip to Norfolk.
There were 14 injuries on the coach, all minor. Five of the injured were taken to West Suffolk hospital.
There were four people in the Mercedes. A spokesman for Suffolk Police said all four of people in the car were hurt, all of them were taken to Addenbrookes in Cambridge with serious injuries, three of the passengers are said to be in a serious conditon.
The people in the Mercedes were believed to be two adults and two children.
The other car passenger was taken to the Norfolk and Norwich University Hospital.
Those injured aboard the coach are believed to have minor injuries, but five of the teenagers were taken to the West Suffolk Hospital for treatment.
The East of England Ambulance Service were also called to the scene and airlifted three of the injured to hospital.
Around 20 patients have been declared as walking wounded.
Drivers are advised to avoid the area but the road is expected to reopen in 30 minutes.