Around 200 people working at Royal Mail's processing centre in Cambridge have had their jobs put at risk after it was announced the site would close.
Royal Mail said today it would be moving most of the work carried out at the centre to Peterborough and Chelmsford.
The transfer is expected to be completed by early 2014. Once Cambridge mail centre is closed, the site will be sold.
In addition, Royal Mail is relocating its mail collection services which are currently based at Cambridge mail centre to Cambridge delivery office.
The decision follows a review of Royal Mail's processing operations in Cambridge that began in February 2012.
The company said, in Cambridge, mail volumes of items posted to addresses in the city and surrounding area from other parts of the country have fallen by 32.6% in the last five years.
A spokesman for Royal Mail said: "We are confident that anyone wishing to continue working for Royal Mail will have the opportunity to do so if they are reasonably flexible.
"Royal Mail’s aim is to minimise job reductions and it remains our intention to make changes without compulsory redundancies."
Ricky McAulay, Processing and Collections Director for Royal Mail East said: “These changes to our operations in Cambridge will, unfortunately, impact on some colleagues.
"However, change is absolutely essential to meet customers’ expectations of a world class postal service, ensure we operate efficiently and provide a great quality of service in a smaller and radically changing market."