Luton Town are aiming to become the first non-league side to qualify for the quarter-finals of the FA Cup since 1914.
Luton set up their 5th round clash with Millwall by beating Norwich City 1-0 at Carrow Road.
Bedfordshire Police have promised a "large and visible presence" at the game at Kenilworth Road.
In 1985 and FA Cup match between the two sides ended in violence.
Kick off is at 12:45pm. For all the latest on the match click here.