The world-famous heart transplant hospital, Papworth in Cambridgeshire, has been told it will no longer be able to offer medical treatment to adults born with heart defects.
The hospital, which specialises in heart surgery, will lose its non-surgical Level Two centre.
It means it will no longer be able to treat adults with congenital heart disease - conditions they've had since birth.
The hospital has been performing pioneering surgery for more than 30 years, but could now lose hundreds of thousands of pounds in funding.
In a statement Papworth said it was disappointed with the decision.
NHS England is cutting the number of specialist cardiac centres by a third.
It's likely that the Norfolk and Norwich hospital will be the only unit in the Anglia region able to carry out some specialist heart treatment.