Following the success of Team GB at the Olympics, the spotlight will soon fall on Rio once again.
There's just a few hours until the Opening Ceremony for the Paralympics will begin.
There are 23 different sports in this year's Games, including two new sports, Para triathlon and canoeing, added to the lineup for the very first time.
Britain will target 121 medals, one more than at London 2012.
Almost 30 athletes from the region will be in action over the ten days, with some defending their respective titles.
So who are the competitors from the East in the Paralympics GB Squad to look out for?
1. Jessica Jane Applegate, Swimming
The Norfolk swimmer impressed after winning double gold in the pool at London 2012 and went on to become the world champion in the 200m Freestyle and 100m Backstroke.
2. Jody Cundy, Cycling
Cambridgeshire track-cyclist Jody Cundy is one of the veterans in the squad, preparing for his sixth games. He's a lower leg amputee, and a former swimmer who won gold on the bike at the 2008 Games in Beijing.
3. Jonnie Peacock, T44 Men's 100m
Cambridgeshire amputee-sprinter Jonnie Peacock was one of the stars in London four years ago after winning the 100 metres. He's struggled with injury over the past 18 months but is hoping to emulate the success of Jason Kenny.
4. Jonathan Drane, Judo
The 29-year-old will compete in the visually impaired category in the under 81 kilogram class. He hails from the same club as Norfolk Olympian Colin Oates.
5. Ellie Robinson, Swimming
The fifteen year old swimmmer from Northampton will compete in her first Paralympics. Robinson, who has a form of dwarfism, set a new British record at the Para-swimming trials with 36.34 seconds.