Storm Doris has swept into the Anglia region with 80 mph winds leaving a trail of destruction and disruption.
11 people were taken to hospital after a double-decker bus overturned near Wisbech in the Fens.
The East of England Ambulance Service was called to the scene at Lynn Road at 1.14pm after the X1 service blew over between West Walton and Walton Highway.
First Buses said they were withdrawing the Norwich to Peterborough service until the winds die down.
The double-decker was a number of incidents where vehicles were blown off the roads or overturned across the Anglia region.
The wind gusts reached 81mph at Weybourne on the north Norfolk coast having peaked earlier in north Wales at 94mph.
There was disruption across the rail network as trees were blown down onto power lines.
Rail company Greater Anglia told passengers not to travel between London Liverpool Street and Stansted/Cambridge after power lines were brought down.
The East Coast Main Line was blocked when large metal sections of roof from a nearby building were blown on to the railway in Sandy, Bedfordshire.
Network Rail advised that "Storm Doris has caused significant disruption throughout the country", with an enforced speed limit on some lines.
With fallen trees, objects caught in overhead wires, heavy rain, flooding and debris on the tracks causing delays across many services, a spokesman said employees are "doing all we can to keep the network running".
A driver had a lucky escape at Witcham near Ely in Cambridgeshire after getting out of their car before a tree fell across it.
The high winds have ripped part of the roof off Gorleston Baptist church.
The building usually doubles as a foodbank on a Thursday and serves meals to vulnerable people but has had to be closed.
The Orwell Bridge on the A14 near Ipswich in Suffolk has been closed for much of the day causing major delays on the diversion routes.
The QEII bridge at the Dartford Crossing has also been closed with southbound traffic on the M25 being forced to use one of the tunnel bores.
At 5pm more than 40,000 homes across Cambridgeshire, Essex, Norfolk and Suffolk were without electricity.
The emergency services in Norfolk were urging people to consider if their journey is absolutely necessary.
Officers from Norfolk Constabulary, Norfolk Fire and Rescue and the East of England Ambulance Trust took nearly 400 calls specifically related to the storms between 8am and 5pm.