Ipswich Town manager Mick McCarthy says he may have to look for fresh blood to bolster his midfield after losing another player to a long-term injury.
Teddy Bishop will miss the rest of the season after a hamstring injury which requires surgery.
He joins seven other senior midfielders, including Cole Skuse, Tristan Nydam and Flynn Downes, on the sidelines, ahead of Saturday's SkyBet EFL Championship contest with Derby County.
McCarthy will have Kevin Bru back for the visit of the Rams, who are managed by Gary Rowett.
Bru, who missed the Boxing Day game against Queens Park Rangers, may finish the season at Portman Road having been previously told he was free to leave.
Norwich City won't have defender Marco Stiepermann available for their trip to Burton Albion.
The 23 year old German is still struggling with a groin problem which kept him out of the Boxing Day win at Birmingham.
However head coach Daniel Farke hopes to have Wes Hoolahan and Cameron Jerome fit available very soon. Both are back in training after injuries.
Meanwhile there's been speculation linking defender Russell Martin with a move to the Scottish Premiership.
Reports claim the 31 year old is a loan target for Glasgow Rangers.
Goalkeeper Remi Matthews, however, has returned to EFL League One Plymouth Argyle on loan for the rest of the season.
League One rivals MK Dons and Peterborough United go head-to-head, with both clubs in contrasting form.
Posh are seeking a fifth straight win in all competitions. They've scored three or more goals in each of their last four victories, the latest a 3-1 win at promotion-chasing Bradford.
But MK Dons, who only sit three points clear of the drop zone, haven't won in League One since mid-November and have enjoyed only three league victories at Stadium MK this season.
Only Gillingham have won fewer home games so far this campaign.
In League Two Luton Town could extend their four point lead at the top with a win at Port Vale.
That's assuming second placed Notts County drop points at Swindon, the team Luton scored five goals against on Boxing Day.
Saturday's SkyBet EFL Games - 3.00pm kick-off unless stated
Burton Albion v NORWICH CITY
IPSWICH TOWN v Derby County
MK DONS v PETERBOROUGH UNITED
Portsmouth v NORTHAMPTON TOWN
SOUTHEND UNITED v Shrewsbury Town
CAMBRIDGE UNITED v Crewe Alexandra
Chesterfield v COLCHESTER UNITED
Crawley Town v STEVENAGE
Port Vale v LUTON TOWN