The A47 Acle Straight in Norfolk was closed for more than eight hours on Saturday following a crash between a lorry and a car.
The road was blocked in both directions after the lorry jackknifed across the carriageway.
The collision happened just after 8am and emergency services were at at the scene for most of the day.
Police advised motorists to plan alternatives routes and also warned people to take care on the county's other roads due to icy conditions.
The road eventually reopened at 4pm. It's not thought that anyone was injured.