The Trade Union, Unite, said the planned closure of Coca-Cola's manufacturing site in Milton Keynes and distribution warehouse in Northampton is a "body blow for local economy."
The drinks giant said the total number of job losses would be 288 and that the sites would close in 2019.
The firm said the changes were necessary because they would provide "significant productivity improvements" in its manufacturing and distribution process.
Unite regional officer Sally Mortimer said: "The closure of the Northampton distribution site is a body blow for the local economy as about 200 jobs are at risk at a challenging time for the UK economy generally.
"We don't accept the company's case that this site is not 'customer friendly' as it is in the centre of England with excellent motorway connections and transport links.
"During the consultation period, we will strongly be making that case for the site to stay open and our red line is that there should be no compulsory redundancies."