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John Whittingdale should withdraw from his role regulating the press, the shadow culture secretary said.
Labour's Maria Eagle said for the public to have "any confidence" in the Government's approach to press regulation then Culture Secretary Mr Whittingdale should step aside from any decision making.
John Whittingdale refused to be drawn on the appropriateness of his role as Culture Secretary on Wednesday.
The Conservative MP declined to comment this morning following admissions he had a relationship with a prostitute.
He broke it off after discovering someone was trying to sell the story to the press.
Latest ITV News reports
There was no conspiracy between newspapers over the Whittingdale affair, but there is circumstantial evidence involving Tom Watson.
A Downing Street spokesman said the PM has 'full confidence' in the Culture Secretary after campaigners claim his role has been compromised.