Campaigners are calling for the speed limit on the A14 to be lowered to 50 miles an hour.
It comes a week after there was widespread disruption on the road following a collision involving two lorries and a car.
The current speed limit is 70 miles and hour.
Overnight roadworks start again tonight along the A14 in Cambridgeshire.
The section between Histon and Girton will be closed from 8pm tonight until 6am tomorrow morning.
It will mean diversions around junction 32.
A major government announcement is expected in the next hour on a multi million pound scheme to upgrade parts of the A14. The road runs from the Port of Felixstowe to the M1 in the Midlands and is used by thousands of drivers every day.
Ministers hope the new investment will improve journey times and reduce delays.
Suffolk businesses are being held back because of delays on the A14, according to the county's Chamber of Commerce.
It claims firms who use the road are at an immediate disadvantage because frequent delays mean higher fuel costs.
Another series of overnight closures begins on the A14 tonight.
From 8pm this evening, to 6am tomorrow the road will be completely closed westbound between junctions 32 and 36. It will also be fully shut eastbound between junctions 31 and 32. Diversions will be in place.
Work is already ongoing on the A14 for the Girton to Histon Pinchpoint programme. A national programme, it involves making improvements to busy points all around the country's road network. The aim is to stimulate growth in the local economy, relieve congestion and improve road safety.
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Transport Minister John Hayes is due to visit sections of the A14 later to see how different projects are progressing.
One of his focuses will be the £16 million scheme to increase capacity and alleviate congestion between Giron and Histon just north of Cambridge.
There 10 miles of queues on the A14 in Cambridgeshire after an accident at 5.50am this morning, between a lorry and two cars. One car has crashed into the central reservation.
The accident happened at J30 Oakington and Dry Drayton. Traffic is now backed up to J24 at Godmanchester the A1198 and B1044.
Lanes 2 and 3 are closed while emergency services deal with the accident.
There are also reports of westbound traffic slowing down to look at the accident, causing some delays there too.
There are around 8 miles of queues on the A14 eastbound heading towards Cambridge this morning after an accident just before 6.00am.
It happened near Junction 30 at Oakington and Dry Drayton and there are currently delays back to Junction 25 Hemingford Abbotts. Lanes 2 and 3 are closed.
Cambridgeshire police say that westbound is also slow because people are slowing down to look at the accident.
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