The A14 northbound is closed between the Spittals interchange near Huntingdon and the A1(M) near Alconbury after a lorry overturned.
Traffic is being diverted along the A14 westbound and then north onto the A1 at junction 22.
Police are warning the road is likely to be closed for several hours and says that long delays are likely.
The Highways Agency is warning drivers of significant delays on the A14 northbound in Cambridgeshire after a lorry overturned. Police say the road could be closed until the evening rush hour.
A lorry carrying clothing overturned just before 10am and the northbound A14 spur between junction 23 and the A1(M)/A14 has been closed. Emergency services are currently at the scene but there are no injuries.
Traffic is being diverted along the A14 towards junction 22, followed by the A1 northbound to re-join the A1(M).
The A14 eastbound is blocked in Cambrideshire with queueing traffic due to accident. Three vehicles involved near J24 A1198 (Godmanchester) heading towards Cambridge.
The A14 spur westbound is also closed due to overturned lorry between J23 A141 (Spittals Interchange, Huntingdon) and A1(M) J14 Alconbury.
There is a diversion via the A1 at Brampton.
Staff at a nature reserve in Cambridgeshire have started a petition against plans to build a road through ecologically important wildlife sites.
Cambridgeshire County Council is consulting with local residents on a new road which would link Hartford Road, near Huntingdon, to the A14 at Godmanchester.
Police are appealing for witnesses after a stolen van was driven the wrong way down the M11 and A14 for nearly 50 miles.
Police say up to 100 vehicles, including HGVs, were forced to dodge the van as it was driven from Essex into Cambridgeshire to escape a police pursuit.
The van joined the M11 at Hastingwood driving north on the southbound carriageway.
Essex police say vehicles monitored the van from the northbound carriageway while a police helicopter flew overhead.
The van stopped after crashing into an HGV near Junction 24 of the A14 at Godmanchester.
A 19-year-old man from Romford was arrested on suspicion of aggravated taking a vehicle without consent, dangerous driving, no insurance, no licence and failing to stop for police.
A driver doing 118 miles an hour on the A14 at Girton was the fastest recorded by speed cameras in Cambridgeshire in the past year.
The police have released the top five speeds in response to a Freedom of Information request.
Two motorists were also clocked doing 116 miles an hour on the A14 near Huntingdon.
Works on improving the A14 in Cambridgeshire get underway today, an extra lane is being put in between Girton and Histon on both sides of the road.
The work will take place primarily during the day using narrow lanes with a 50mph speed limit.
Some overnight lane and road closures will be required and traffic will be diverted at times.
The work is part of a £317 million pinch point improvement programme designed to boost local economies, reduce congestion and improve safety on the strategic road network in England.
It should take 8 months to complete.
Delays on the A14 are costing Suffolk businesses £140 million a year according to a new report on the impact the road is having on the county's economy.
The study by accountants firm Ernst and Young says the time lost in delays across the A14 costs companies over £110 million with a further £29 million lost by supply chain industries.
They believe ending congestion on the road could instead generate revenue and create thousands of more jobs.
There will be an abnormal load travelling through Norfolk and Suffolk on Wednesday.
The steel tank will be escorted from the A11 at Snetterton to the Cambridgeshire border of the A14 from 9.30am.
Delays are expected through the roadworks at Elveden.
The road is closed and there is stationary traffic due to an accident in Cambridgeshire on A14 westbound between J29 B1050 (Bar Hill) and J26 A1096 London Road (St Ives) towards Huntingdon.