A crane will start removing a derailed freight train near Ely later this morning.
Network Rail says it will take two days to lift the eleven wagons. Work can then begin to replace a quarter of a mile of damaged track.
They hope to re-open the railway on Monday.
Passengers travelling to Peterborough from Cambridge, Bury St Edmunds and Norwich are affected.
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A major study led by Cambridge University found that overweight people were at risk of heart disease no matter how healthy they were.
Experts say getting down to a healthy weight is still important even if your blood pressure, blood sugar and cholesterol are normal.
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A freight train has derailed between Ely and Peterborough leaving the line blocked and causing major disruption for commuters.
CrossCountry Trains say the incident occurred at approximately 14:40 on Monday 14 August, when 11 wagons of a 33 wagon freight train travelling north of Ely derailed. No one was injured.
Network Rail engineers expect that the recovery to take several days. Passengers are urged to check with their train operators before traveling this evening and over the next few days.
East Midland, Greater Anglia and London Midland say they are accepting CrossCountry tickets on any reasonable routes.
"This is a serious incident and our engineers are on site working tirelessly to resolve the issue as quickly as possible. The recovery is very complex and not helped by the rural location and will take several days. I understand how frustrating this is for passengers and would like to thank them for their patience while we work to get services up and running again.”