Colchester United duo Frankie Kent and Denny Johnstone have both been ruled out for the rest of the season.
Centre back Kent has ruptured ligaments in his ankle, while forward Johnstone has suffered a tear in his knee cartilage.
However there is better news concerning defender Tom Eastman who could be back in action before the end of the campaign.
Tom is having a series of Prolotherapy injections to heal the rupture in his ankle ligaments.
He had one earlier this week and will have another one or two depending on how the specialist thinks it's going.
An operation was an option for Tom and that would have meant him joining Frankie and Denny in being out all season.
This course of action has a shorter recovery time and gives us the chance to get Tom back for the last few weeks of the season.
Colchester United have signed former Luton Town goalkeeper Dean Brill on a free transfer.
The 31-year-old was recently released by Scottish side Motherwell, where he failed to make an appearance.
Brill, who has also played for the likes of Oldham Athletic and Barnet in his career, will now compete with Sam Walker and Dillon Barnes for the number one jersey.
The U's have also completed a permanent move for Swindon Town midfielder Sean Murray on an initial contract until the summer of 2018.
Meanwhile, Stevenage have signed Scunthorpe United midfielder Jack King on a free transfer.
He's agreed an 18-month deal, while young Arsenal striker Kaylen Hinds has also joined on loan.
In terms of outgoings, forward Rowan Liburd has moved on loan to Leyton Orient.
Colchester United have signed promising Huddersfield Town striker Rekeil Pyke on loan until the end of the season.
The 19-year-old has impressed for the Terriers' development side this season, and has also been out on loan at Wrexham in the Conference.
Delighted to sign for @colu_official on loan until the end of the season, Can't wait to get started.⚽️
Pyke is yet to make his debut for Huddersfield's first team, but did feature in some of their pre-season games.
Meanwhile, 20-year-old Colchester midfielder Chris Regis has left the club.
Colchester United have rejected a bid from local rivals Ipswich Town for their winger Brennan Dickenson.
The 23-year-old has been a big hit since joining on a free transfer in the summer.
The former Gillingham man has scored seven goals in 23 appearances to help the U's into the League Two play-off positions.
Ipswich are in the market for fresh recruits to help breathe life into their stuttering Championship campaign, and wrapped up a loan deal for Leeds midfielder Toumani Diagouraga yesterday.
League Two Colchester United have signed Cardiff City midfielder Tommy O'Sullivan for an undisclosed fee.
The 22-year-old has signed a contract with the U's until June 2018.
He made three appearances for Cardiff's first team after coming through the club's academy system and has also spent time on loan at Port Vale and Newport County.
O'Sullivan is the second Cardiff player to join John McGreal's side this month, following the arrival of Eli Phipps earlier this week.
Southend United have signed former Ipswich Town striker Frank Nouble on a deal until the end of the season.
The 25-year-old was recently released by League One rivals Gillingham after joining them on a short-term contract in the autumn.
Nouble has also played for the likes of West Ham and Coventry City in a nomadic career, as well as enjoying a spell at Chinese club Tianjin Quanjian.
Meanwhile, Colchester United have signed Cardiff City forward Eli Phipps for an undisclosed fee.
Colchester United's manager John McGreal has been named League Two Manager of the Month for December.
The U's ended the month unbeaten to lift themselves to just outside the play-offs having earlier been fighting relegation.
McGreal saw off competition from Cambridge United's Shaun Derry, Gareth Ainsworth at Wycombe Wanderers and Exeter City's Paul Tisdale.
He says the award is down to a team effort.
It’s very flattering to receive the award...but the credit must go to the players for the way they’ve adapted to what we’ve asked them to do.
We’ve changed the system, had players come back from injury and the whole squad has had the belief and talent to go out there and perform.
Even during the run without winning, they believed in themselves and the results in December were a reward for their hard work and application.
They’ve shown what they are capable of and we all want to continue December’s form into the New Year and the second half of the season.
Colchester manager John McGreal and Cambridge United's Shaun Derry are both up for the League Two Manager of the Month award for December.
They're up against Gareth Ainsworth at Wycombe Wanderers and Exeter City's Paul Tisdale.
Colchester ended the month unbeaten to lift themselves to just outside the play-offs having earlier been fighting relegation.
Meanwhile, Cambridge moved into play-off positions after they're unbeatable run and only dropping two points in their last seven league matches.
The winner will be announced on Friday.
We look at how our clubs are coping without the emergency loan window as they prepare to do business again in January.Read the full story ›
Colchester United have signed former Shrewsbury Town defender Jermaine Grandison on a free transfer.
The 26-year-old has been on trial with the U's recently and has done enough to earn a deal until the end of the season.
Grandison made more than 150 appearances during his time at Shrewsbury, but was released in the summer.