Ipswich Town manager Mick McCarthy has confirmed that midfielder Luke Hyam will miss the next month through injury.
It means that the 24-year-old will play no part in Sunday's East Anglian derby.
Town also have fitness concerns over striker Brett Pitman and new signing Conor Grant who will both be missing for tomorrow's clash at Wolves.
Forward David McGoldrick is already facing a long spell on the sidelines after he sustained ankle ligament damage.
Luke Hyam is also going to be out for a few weeks, maybe three or four.
We all thought it was bone bruising and it is, but there is nerve damage as well and that is taking a while to heal.
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Ipswich Town have been dealt a major blow with the news that striker David McGoldrick will miss the next two months through injury.
The 28-year-old sustained ankle ligament damage in Tuesday's EFL Cup defeat against Stevenage.
Town have re-signed Luke Varney to provide cover.
It’s devastating news for Didz and it’s a real freak injury as well.
He went on at half-time and almost his first touch, he jumped for the ball and landed awkwardly. He thought he has rocked his ankle and ran it off.
It turns out he has damaged the ligament in his angle and we are looking at six to eight weeks on the sidelines. He will see the surgeon on Monday and hopefully he won’t need an operation. If he does, it could be 12 weeks out.
Ipswich Town have re-signed striker Luke Varney on a short-term contract until January.
The 33-year-old was released by Town this summer but has now been offered a return to Portman Road to cover for an injury to Brett Pitman.
Varney could be in line to make his third debut for the club at Brentford tomorrow.
He’s a good player and has been a good servant to us. He’s a great personality. We all love him, the staff, the players.
With McGoldrick injured, we had to try and get someone in before the weekend. That was never going to be easy but I knew Varney would be fit and could do a job for us.
There were clubs interested in him but I rang him yesterday and it was all sorted in no time.
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Video report by ITV News Anglia's Donovan Blake
The new domestic football season kicks off today and clubs across our region will be hoping for a successful campaign.
Norwich City start life back in The Championship away at Blackburn Rovers, while Ipswich Town entertain Barnsley at Portman Road.
We've been looking at how our region's teams might fare this year as our Football League clubs prepare for another campaign.Read the full story ›
Ipswich Town have signed Everton winger Conor Grant on a season-long loan deal.
The 21-year played more than 20 games for Doncaster Rovers last season but was unable to prevent them being relegated to League Two.
Grant has also spent time on loan at SPL club Motherwell and could make his Town debut against Barnsley on Saturday.
Ipswich Town manager Mick McCarthy speaking about his new loan signing Conor Grant