Police are advising drivers to avoid the M25 until mid-afternoon after a lorry fire closed the carriageway on both directions in Hertfordshire.
The section between junctions 21a and 23 near the South Mimms services is expected to be closed until 3pm.
Long tailbacks have built up on surrounding roads.
The M25 is closed in both directions in Hertfordshire because of a lorry fire and smoke blowing across the carriageway.
The section affects is between junction 21a for London Colney and junction 23 for South Mimms and the A1(M).
The Highways Agency says the road is expected to re-open from 3:00 pm.
Two lanes closed due to strong winds on M25 Dartford Tunnel anticlockwise from A282 (Dartford River Crossing toll booths).All traffic is using one tunnel due to the closure of the QE2 Bridge.
A German lorry driver has been charged with causing death by dangerous driving following a ten-vehicle crash on the M25 in Essex.
Anton Maizen, 58, from Darmstadt in Germany, was arrested following a collision on the M25 at near Lakeside on Tuesday 2 April.
He has been charged with causing death by dangerous driving as well as causing serious injury by dangerous driving and was due to appear before Basildon magistrates court on Thursday.
A 79-year-old man from Ilford was certified dead at the scene of the collision. Five others including a child were taken to hospital.
The M25 is blocked anti-clockwise between the A12 and M11 junctions due to accident.
The M25 at Aveley between junctions 29 and 30 was fully reopened at 9pm last night, following a fatal collision involving ten vehicles. The collision happened at 12.30pm on the clockwise carriageway and involved four articulated lorries and six cars.
One person, a man in his 70s from east London, was certified dead at the scene. Two people were airlifted to the Royal London Hospital and a number of other people received less serious injuries.
Two lorry drivers were arrested at the scene on suspicion of causing death by dangerous driving. A 43-year-old man from Poland was later released without charge, while a 58-year-old man from Germany remains in police custody.
One person has died and five have been taken to hospital following an eight-vehicle crash on the M25 near Lakeside in Essex.
Diversions are likely to be in place for most of Tuesday evening.
Essex police have arrested two lorry drivers on suspicion of dangerous driving following a multiple pile-up on the M25 near Lakeside.
One person was killed and five more including a child were taken to hospital following the crash involving three lorries and five cars.
The collision happened between Junctions 29 and 30 shortly before 12:30pm. A section of the clockwise carriageway has been closed with traffic being diverted off and back on the motorway. The road is expected to be closed until later on Tuesday evening.
One person has been killed and five people including a child have been taken to hospital after a crash on the M25 near Lakeside in Essex.
The crash involving three lorries and five cars happened around 12.30pm and the southbound carriageway is closed.