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Addenbrooke's Hospital says it is currently experiencing significant issues with its computer network.
People are being asked not to go to A&E unless absolutely necessary and ambulances are being diverted to other hospitals.
The Cambridge University Hospital's Trust says emergency surgery is continuing but elective operations have been cancelled.
Outpatients should assume that appointments are going ahead unless they hear from the the hospital.
In a statement the trust says technical experts are working to resolve the problem as soon as possible and staff are working to a well-versed business continuity plan.
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The jury has retired to consider its verdicts in the case of two men charged with dangerous driving after a crash on the M1 in which eight people died.
Four others were seriously injured when a lorry crashed into the back of the minibus they were travelling in and pushed it under another lorry parked on the nearside lane.
David Wagstaff, 54, and Rysiard Masierak, 32, both deny causing death by dangerous driving but Wagstaff admits causing death by careless driving.
Masierak denies causing death by careless driving while over the alcohol limit.
Reading Crown Court heard he'd parked his lorry on the nearside lane of the M1 for 12 minutes, later saying he felt unwell.
The court heard Wagstaff was on a hands-free phone call in his lorry and lost concentration hitting the minibus at 56mph on cruise control without braking.
It was pushed into Masierak's lorry near the Newport Pagnell sliproad on the Southbound M1.
Masierak was found to be over the drink-drive limit and had earlier been seen to be driving erratically, even driving the wrong way around a roundabout and a slip road.
Among the injured, a little girl who lost both parents in the crash. They were being driven with family and friends at the start of a trip to Disneyland in Paris on the August Bank Holiday weekend.
The jury has been sent home for the night and will resume deliberations tomorrow.
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