The local MP for the historic Colman's mustard site in Norwich has described the decision by Unilever to shut the factory as a "body blow for the workers and the city of Norwich."
Clive Lewis, the Labour MP for Norwich South said: "Colman's is an iconic brand for this city and this news is going to be devastating. It's a terrible way to start 2018 coming on the back of Britvic's announcement that they will leaving the same site."
Colman's Mustard was started near Norwich in 1814 and moved production to its current site in the city in 1858.
The Conservative MP for Norwich North, Chloe Smith, said the decision was "bitterly disappointing" and a "real blow" to workers.
She said it was a distressing day for Norwich.
"Senior figures in Government have stood with us throughout the last few months to try to keep these historic brands in Norwich.
"The grassroots campaign has been a credit to the city and that has its reward in that the Colman's brand will remain in Norwich and the supply chain may remain in place.
"I am fundamentally disappointed that neither of these companies have chosen to keep the bulk of their operations in Norwich. "My first thoughts are with those constituents who may lose their jobs; my focus for the longer term will be that major employers should continue to see Norwich as a great place to be."
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Calls for extra funding for Kettering General Hospital will be made at Westminster.
Northamptonshire MPs Peter Bone, Andy Sawford and Philip Hollobone will be meeting Health Minister Dan Poulter to ask for additional funding.
They're calling for an extra twenty million pounds to improve hospital services and three million for local health care provision. The MP's have lead a campaign to save and improve services at the hospital.
Five Conservative MPs from the Anglia region voted against the Government and helped Labour defeat a motion on Syria. It has battered the UK's foreign policy and some commentators say that the vote has undermined David Cameron's authority.
One Liberal Democrat from East Anglia, the Cambridge MP Julian Huppert, also voted against the coalition motion.
The Conservatives from the Anglia region who voted against were:
David Amess (Southend West)
Richard Bacon (South Norfolk)
John Baron (Basildon & Billericay)
Philip Hollobone (Kettering)
Stephen McPartland (Stevenage)
A further nine Tories from the Anglia region either abstained or were absent for the vote. They were:
Henry Bellingham (North West Norfolk), Nadine Dorries (Mid Bedfordshire), Alan Duncan (Rutland & Melton), Sir Alan Haselhurst (Saffron Walden), Anne Main (St Albans), Sir Jim Paice (South East Cambs), Priti Patel (Witham), David Ruffley (Bury St Edmunds) and Tim Yeo (South Suffolk).
The region's three Labour MPs voted with their party against the Government.
General Lord Dannatt described the Commons vote on Syria as a "victory for common sense".
The former head of the British Army told the BBC the "drumbeat for war" had dwindled among the British public in recent days.
He said: "What has happened today has been a victory for common sense and for democracy, and the will of the people has been expressed through the House of Commons that we don't want to get involved in this - that's the right answer at this precise moment.
"President Obama may well take note of what's happened in Westminster tonight and think again.
"I certainly hopes he thinks again because I'm absolutely convinced the use of explosive ordinance into Damascus at the present moment will make the situation in that very difficult Syrian civil war worse, not better."
The Conservative MP for Clacton, Douglas Carswell, voted in favour of the government motion on Syria which was defeated by the House of Commons by 285 votes to 272.
Democracy works. Mucky, messy, infuriating. But the best way of running our country
Five Conservative MPs from the Anglia region voted against the Government in the debate over Syria helping to defeat David Cameron's motion.
A further nine Tory MPs were either absent from the recall of Parliament or abstained in the crucial vote.
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