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Cottingham Road in Corby, Northamptonshire will be closed for seven months from January 19.
A bridge on the road, which runs over the railway lines, needs to be shut as part of the upgrade of the line between Kettering and Corby.
Network Rail say the bridge will be raised to allow electric lines to run underneath and is due to reopen on August 14.
There's been another day of strike action for rail operator Greater Anglia to contend with as RMT Union members walk out over the role of guards on the network.
Watch a report by ITV News Anglia's Tanya Mercer
Mick Cash is the General Secretary of the National Union of Rail, Maritime and Transport Workers.
Watch an interview with ITV News Anglia's Jonathan Wills
Commuters in our region face a second day of disruption today as walkouts by train workers over rail safety continue.
Greater Anglia is among five companies affected.
The first strike was held Monday, another is due to take place on Friday.
"No one should be in any doubt, these disputes are about putting the safety of the travelling public before the profits of the private train companies."
Greater Anglia is running a full service, staffed partly by managers acting as guards.
A long-awaited report into the future of one of the region's most congested roads will be released later today.
Cambridgeshire County Council will look at a number of options for the A10 which runs all the way from King's Lynn into London.
It's notoriously busy around the stretch from Ely to Cambridge.
The A10 north is a key transport route for economic growth in the region, linking Ely, and other towns and villages to the north, with the city and wider transport network.
Rapid growth has put pressure on the road with peak-time congestion.
Thousands of new jobs and homes are planned along the route over the next decade or so, including 10,000 new homes at Waterbeach alone.
A study was commissioned by the Greater Cambridge Partnership to look out how to address the current challenges. It will be published today (Monday 8th January).
Any proposals will then be considered by all the councils affected.
- Video report by ITV News Anglia's Victoria Lampard
Today marked the biggest increase in rail fares for half a decade- a rise of 3.4%.
Passengers on services in the Anglia region will find they're spending even more for their daily commute.
People have been protesting at stations across the region, while the TUC say their figures suggest commuters in the UK are paying up to five times as much as elsewhere in Europe.
The A47 Norwich southern bypass is blocked eastbound with very slow traffic due to accident at the A140 Ipswich Road junction.
A vehicle has overturned following an accident.
Police and ambulance crews are on scene. The crash is affecting traffic between Norwich and Great Yarmouth.
- Video report by ITV News Anglia's Malcolm Robertson
Stansted Airport had to provide beds and blankets for hundreds of stranded passengers overnight.
The bad weather caused delays and cancellations which left people waiting to re-book tickets.
Stansted temporarily closed its runway twice yesterday due to ice. As a result, 27 inbound and 27 outbound flights were cancelled leaving around 300 passengers in the terminal waiting to rebook flights.
The airport provided beds and blankets for people who couldn't get home or find accommodation.
Stansted said all flights were anticipated to operate as scheduled today although passengers were reminded to check their flight's status before travelling to the airport.
Meanwhile around 50 flights were cancelled at Luton and the airport is also urging passengers to check with their airlines before travelling.
"All affected customers were contacted by email and SMS text message and advised of their rebooking options," Ryanair said in a statement.
"We sincerely apologise to all customers affected by these weather cancellations and disruptions, which are entirely beyond our control."