Both the A1101 Wash Road at Welney in Norfolk and the A1123 Earith Causeway in Cambrideshire are closed due to flooding.
According to the Environment Agency there is more than 4 foot of water (128 cm) on the road in Welney.
The water is nearly a foot deep (28 cm) at Earith. Diversions are in place on both routes.
With further rain forecast in the Anglia region it's likely there will be further problems with flooding into the New Year.
With many rivers running high, a number of Flood Warnings issued by the Environment Agency remain in force in the Anglia region.
Further heavy rain on Saturday in the Anglia region has seen more flood warnings issued by the Environment Agency.