Today is Jeans for Genes Day and people across the region have been wearing their denim to raise money for genetic research.
It's those developments that the family of little Florie-Rae from Hertfordshire are hoping will provide a breakthrough. The 3-year-old suffers from Rett Syndrome.
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Tonight will be chill with lows of 3 deg C ( 37 deg F ) but tomorrow will be generally fine and sunny.
A man has been left with life-changing injuries following a crash in Essex in which five people were hurt.
A seven year old girl has died after being pulled from a swimming pool near Beccles. She was taken unconscious to hospital but later died.