A father from Cambridge has helped launch a clinical trial into a drug which could prevent both his sons developing a serious genetic illness they are carrying.
Black Bone disease progresses during adulthood, and causes brittle bones and heart disease. Dr Nick Sireau gave up work four years ago to concentrate on finding a drug to stop its progress.
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Another gloomy start for many but some brighter spells will develop later.
Here's something that will warm your heart on a cold winters day. We've the latest messages in ITV News Anglia's Christmas Shout Out series.
Low cloud and fog reforming. Mild.