Northampton Saints star Courtney Lawes has been dropped from the England squad to face Ireland at Twickenham.
Lawes misses out in favour of Saracens' Maro Itoje.
It means that Lawes, can play in Northampton's Aviva Premiership clash with Worcester on Saturday.
England Squad: Forwards D Cole (Leicester Tigers), J Clifford (Harlequins), J George (Saracens), D Hartley (Northampton Saints, capt), J Haskell (Wasps), P Hill (Northampton Saints), M Itoje (Saracens), G Kruis (Saracens), J Launchbury (Wasps), J Marler (Harlequins), C Robshaw (Harlequins), B Vunipola (Saracens), M Vunipola (Saracens).
Backs: M Brown (Harlequins), D Care (Harlequins), E Daly (Wasps), O Farrell (Saracens), G Ford (Bath Rugby), A Goode (Saracens), J Joseph (Bath Rugby), J Nowell (Exeter Chiefs), A Watson (Bath Rugby), B Youngs (Leicester Tigers).