The A75 is currently closed between Annan and Dumfries and is expected to remain closed for up to five hours, after a road accident early this morning.
The westbound diversion route is via A75 at Ladyfield, onto the B7020 to Dalton and Lochmaben, onto the A709 and then to the A75 at Dumfries.
The eastbound diversion is the reverse route.
Police are asking motorists to avoid the area if possible.
A 56-year-old man from Maryport was trapped in his lorry after it left the road and ended up in a field.
The accident happened at the Hardgrove Junction on the A75 between Ruthwell and Dalton, just after 6 o'clock this morning.
The driver was initially trapped, but later managed to climb free and was uninjured.
Dumfries and Galloway Police and the fire service helped clear traffic.
The road is expected to be closed, to allow the lorry to be moved.