The A66 has reopened following an earlier crash involving a cyclist and a Toyota Avensis.
The collision happened shortly before 2 o'clock this afternoon.
The driver of the car, a 43-year-old man from Threlkeld, was not injured.
The cyclist, a 60-year-old man from Florida, received serious injuries and was taken to Newcastle hospital via Air Ambulance.
The road was closed for a time while the emergency services attended the incident.
A 60-year-old man from Florida has been taken to hospital in Newcastle with "serious injuries", after his bike collided with a car on the A66.
The accident happened at Threlkeld, near Keswick.
The driver of the car was uninjured in the accident.
Motorists are asked to follow the diversions in place.
Diversions are in place to allow emergency services to deal with the crash on the A66 at Threlkeld, near Keswick.
Travelling towards west Cumbria, motorists are advised to use junction 41 of the M6, travelling along the B5305, Wigton.
Travelling towards Penrith, motorists should follow the diversions in place at the Crossthwaite roundabout, Keswick.
Cumbria Police say that the road will be closed for some time.
The A66 has been closed at Threlkeld following a collision involving a car and a cyclist.
Emergency services are currently at the scene at the junction with Threlkeld, near Keswick.
The extent of the cyclist's injuries are not known at this time.
Motorists are being advised to avoid the area and to seek alternative routes.