The A590 is blocked both ways between the A592 (Newby Bridge Roundabout) and High Newton Road, because a lorry has overturned.
The vehicle was reportedly carrying cattle.
Police are appealing for witnesses following a fatal road crash in south Cumbria.
Frank Rockliffe, who was 85 and from Milnthorpe, was taken by ambulance to the Royal Preston Hospital with serious injuries last week and has since died.
The fatal collision happened at around 5:15pm on Tuesday 13 December on the southbound exit slip road leading from the A590 to Brettargh Holt roundabout.
Anyone with information is asked to contact Cumbria Police's operational support unit on 101 and quote log number 183 of the 13 December.
The A590 between Newby Bridge and Brettargh Holt roundabout has re-opened, after a collision which hospitalised two people.
Two people have been hospitalised after a serious two-car collision on the A590 in south Cumbria.
The Great North Air Ambulance was called to the crash, near Levens, at 10:45am this morning.
They treated the driver of a Peugeot Partner, a man in his seventies who had a serious chest injury, before flying him to the Royal Preston Hospital.
A 68-year-old female passenger in the same car was airlifted to hospital by the North West Air Ambulance.
The 19-year-old male driver of the other car, a Vauxhall Vectra, was uninjured.
The road was initially closed in both directions, but the Westbound lane has now re-opened.
The A590 Eastbound remains closed after an accident at Levens.
It was reported at 10:25am, and two cars were involved.
The accident happened between the A592 (Newby Bridge Roundabout, Newby Bridge) and Cartmel Lane / High Newton Road (Ayside).
The road was closed in both directions between Newby Bridge and Brettargh Holt roundabout, but the Westbound lane has now re-opened.
Motorists are being diverted via the A592 to Windermere.
Work to prevent rocks from falling onto the A590 begin today at Arrad Foot.
The westbound carriage will be closed, with a contraflow system in place on the Eastbound carriageway.
Rock netting will be put up and loose stones will be removed. Highways England say the works are expected to last for 3 weeks.
A motorcyclist involved in a collision on the A590 last Friday (2 September) has died, police have confirmed.
The 41-year-old, from the Bristol area, was airlifted to the Royal Preston Hospital with multiple injuries after colliding with a car at around 2pm on the A590 at Gilpin Bridge.
He died in hospital yesterday evening, and police say his family are being supported by a specially trained officer.
The driver of the car, a 78-year-old woman from Grange-over-Sands, was also taken to hospital following the collision.
She was discharged on Monday after suffering serious injuries.
Police are appealing for any witnesses to the collision to contact PC 396 Mark Jesson of the Mobile Support Group at Kendal on 101.
Two people have been hospitalised after a serious accident on the A590 near Kendal.
Police were called at 13:58pm following a report of a car colliding with a motorcycle.
The motorcyclist suffered serious injuries and was taken to the Royal Preston Hospital.
The driver of the car also suffered injuries (nature of injuries not known at this time) and was also taken to the Royal Preston Hospital.
The road was closed in both directions between Brettargh Holt and Meathop roundabout to allow agencies to conduct recovery work, but one lane westbound has now opened.
Motorists are asked to avoid the area.
The A590 in the Kendal area has been closed in both directions, after a road accident.
The collision happened between Brettargh Holt and Meathop roundabout, and was reported to police at around 2:15pm.
Police are asking drivers to avoid the area.