Two men have been airlifted to hospital following a collision on the A684 between Kendal and Sedburgh Road around 12.30pm today.
A yellow Caterham Seven open top sports car and a blue 52-seater coach from Germany were involved in the crash.
The driver of the sports car, a 41 year old man, and a male passenger were initially trapped in the vehicle and later freed by the fire and rescue services before being airlifted to the Royal Preston Hospital with serious injuries.
The 32 people on the coach, including the driver, were uninjured.
Anyone who may have witnessed the collision or seen the vehicles prior to the incident are being asked to contact Cumbria Police on 101 and ask for PC 1639 Steve Wilson of the Kendal Roads Policing Unit.
The road currently remains closed, but police hope to reopen it within the next two hours.
Two people have been airlifted to hospital in Preston via air ambulance following a collision on the A684 in Cumbria.
The crash involved an open top sports car and a bus. it is understood that no one on the bus was injured.
Three fire engines from Kendal were called to assist emergency services and paramedics at the scene at New Hutton near Kendal.
The fire service used specialist cutting equipment to free the two people from the car so that they could be transported to hospital.
The road remains closed.
The A684 has been closed between Kendal and Sedburgh Road following a crash involving a sports car and a bus.
Paramedics are at the scene, as well as the Fire Service and the Highways Agency.
The collision happened at junction 37 of the M6 just after midday.
The road remains closed and police are advising that it will be for some time.
They are therefore suggesting that motorists use an alternative route.