The A75 at Glenluce has been closed, due to a "small chemical spillage".
Police say at around 1:40pm, a bottle containing an unknown substance was found at the side of the A75 at the Glenluce bypass.
Emergency services are there, and the road has been closed.
Diversions are in place through the village of Glenluce for all traffic travelling east and west.
The fire and rescue service are waiting for specialists to arrive to identify the chemical.
One person has been taken to the Dumfries and Galloway Royal Infirmary as a precaution, having been in direct contact with the substance.
Police say there is no risk to the wider public.
A man has died following a road accident involving a lorry, on the A75 in Dumfries on Thursday 26 March.
William Hanlin, 47, from Dalbeattie, was driving an eastbound Vauxhall Astra, which collided with a westbound articulated lorry at Cuckoo Roundabout.
He died at the scene.
The man driving the lorry was taken to Dumfries and Galloway Royal Infirmary and treated for minor injuries.
He was since been released.
Police are asking for witnesses to the crash to contact them on 101.
A 67-year-old woman has died following a crash involving 2 vans in Dumfries and Galloway this morning (Saturday 21st).
Police were called to the crash on the A75 near Eastriggs at around 11.15am, involving a Renault van and a Mercedes van.
The 67-year-old female passenger of the Mercedes was pronounced dead at the scene.
Another passenger, a 38 year-old woman, was taken by ambulance to Dumfries and Galloway Royal Infirmary where she is being treated for her injuries. Hospital staff describe her condition as stable.
The 67 year-old driver of the Mercedes was conveyed to DGRI for a chest injury.
The two male occupants of the Renault were taken to Dumfries and Galloway Royal Infirmary as a precaution.
Enquiries are continuing into the cause of the crash and Police Scotland are urging witnesses to contact them on 101.
The A75 is closed in both directions between Newton Stewart and Glenluce due to a road traffic accident.
Drivers are being asked to expect lengthy delays and follow the diversion signs in place.
A photograph has been released of James McGregor, who died in a car crash on the A75.
The 67-year-old, from Darlison Avenue in Dumfries, was travelling with four family members when his silver Ford Focus C-max crashed into trees west of Annan at 3.30pm on 25th November.
His family were treated for minor injuries in hospital but have since been released.
Police Scotland are appealing to witnesses to get in contact to help with the investigation into the circumstances of the crash.
A man who died in a crash on the A75 has been named by police as James McGregor from Darlison Avenue in Dumfries.
The 67-year-old was travelling with four family members when the car, a silver coloured Ford Focus C-max, crashed into trees west of Annan at 3.30pm on 25th November.
His family were treated for minor injuries at Dumfries and Galloway Royal Infirmary and have since been released. The road was closed for four hours.
Anyone with information about the crash is asked to contact Police Scotland.
A man has died after a crash on the A75 in which four members of his family were also taken to hospital.
The car they were all travelling in crashed into trees west of Annan in Dumfries and Galloway, at 3.30pm on 25th November.
The driver, a local man believed to be 67-years-old, died at the scene.
His family were treated for minor injuries at Dumfries and Galloway Royal Infirmary. They have since been released. Police Scotland are appealing for any witnesses to contact them.
A South of Scotland MSP has called for a bypass to be constructed on the A75, around Springholm and Crocketford.
Lib Dem Jim Hume believes the increasing number of lorries on the road makes it unsafe for local residents:
Three people have been left injured after a two car collision on the A75 Gatehouse Bypass, Gatehouse.
One fire engine was called to the scene of the incident today, Wednesday 20 August, at 1:10pm.
Three people involved are said to have been 'slightly' injured.
The A75 is closed after six vehicles, including three HGV's, were involved in a crash.
The incident happened at about 8:15am today, Friday 20 June, at Mouswald Banks near Colin, Dumfries.
Police are asking for anyone who saw a small blue car, that left the seen, or a moped rider at the time of the incident to get in touch on 101.
At this stage, Police say there are no serious injuries.
The road is expected to be closed for a considerable amount of time while all vehicles are recovered.
Diversions will be in place and there may be some delays. Motorists are advised to avoid the area.