The A75 is closed in both directions between Newton Stewart and Glenluce due to a road traffic accident.
Drivers are being asked to expect lengthy delays and follow the diversion signs in place.
A photograph has been released of James McGregor, who died in a car crash on the A75.
The 67-year-old, from Darlison Avenue in Dumfries, was travelling with four family members when his silver Ford Focus C-max crashed into trees west of Annan at 3.30pm on 25th November.
His family were treated for minor injuries in hospital but have since been released.
Police Scotland are appealing to witnesses to get in contact to help with the investigation into the circumstances of the crash.
A man who died in a crash on the A75 has been named by police as James McGregor from Darlison Avenue in Dumfries.
The 67-year-old was travelling with four family members when the car, a silver coloured Ford Focus C-max, crashed into trees west of Annan at 3.30pm on 25th November.
His family were treated for minor injuries at Dumfries and Galloway Royal Infirmary and have since been released. The road was closed for four hours.
Anyone with information about the crash is asked to contact Police Scotland.
A man has died after a crash on the A75 in which four members of his family were also taken to hospital.
The car they were all travelling in crashed into trees west of Annan in Dumfries and Galloway, at 3.30pm on 25th November.
The driver, a local man believed to be 67-years-old, died at the scene.
His family were treated for minor injuries at Dumfries and Galloway Royal Infirmary. They have since been released. Police Scotland are appealing for any witnesses to contact them.
A South of Scotland MSP has called for a bypass to be constructed on the A75, around Springholm and Crocketford.
Lib Dem Jim Hume believes the increasing number of lorries on the road makes it unsafe for local residents:
Three people have been left injured after a two car collision on the A75 Gatehouse Bypass, Gatehouse.
One fire engine was called to the scene of the incident today, Wednesday 20 August, at 1:10pm.
Three people involved are said to have been 'slightly' injured.
The A75 is closed after six vehicles, including three HGV's, were involved in a crash.
The incident happened at about 8:15am today, Friday 20 June, at Mouswald Banks near Colin, Dumfries.
Police are asking for anyone who saw a small blue car, that left the seen, or a moped rider at the time of the incident to get in touch on 101.
At this stage, Police say there are no serious injuries.
The road is expected to be closed for a considerable amount of time while all vehicles are recovered.
Diversions will be in place and there may be some delays. Motorists are advised to avoid the area.
The A75 between Gretna and Stranraer Road is now re-open after a crash.
A mile stretch of road had been closed earlier this morning after an incident involving a motorcycle and a camper van.
The A75 between Gretna and Stranraer Road is blocked after a crash.
A mile stretch of road has been affected after an incident involving a motorcycle and a camper van.
Police Scotland are currently at the scene.
No diversions are currently in place but officers are regulating the flow of traffic.
A number of historic artefacts have been uncovered during the construction of a new bypass in Dumfries and Galloway.
During work to improve the road near Dunragit thousands of Mesolithic and Neolithic were uncovered, and they have now been unveiled by Scotland's Transport Minister.
Fiona McIlwraith reports.