A woman has died after a crash on the A75.
An lorry, VW Tiguan and a Ford Ka were involved.
The incident took place on the Dumfries bypass between Locharbriggs and Lincluden.
The road is closed and is expected to stay closed for some time to allow for a full crash investigation to take place.
Diversions have been put in place which takes traffic through Dumfries town centre.
Motorists are asked to bear this in mind if planning to travel in Dumfries over the next while due to the expected traffic queues that are likely.
Anyone who was driving in the area at the time and who witnessed the crash is asked to call Police Scotland on 101.
It has been a day of huge delays and huge diversions on one of the region's busiest roads.
A 78-year-old local man died in a three car crash on the A75 this morning at Gatehouse of Fleet in Dumfries and Galloway.
Drivers, including hundreds of lorry drivers heading to the ferry port of Cairnryan, faced an 80 mile diversion as the road was shut for several hours.
Our Dumfries and Galloway reporter, Fiona McIlwraith has spent the day at the scene.
Watch her full report below.
Police Scotland are on the scene of a fatal crash on the A75 that happened this morning.
"About 6.40am this morning there's been a three vehicle road traffic collision on the A75 just east of Skyreburn tearoom, it's obviously an early part of our enquiries just now, but we're looking into the crash just now and there are crash investigators at the locus doing their work as we speak.
"It's caused a far amount of disruption, especially for ferry traffic, coming along, as you can see, there's quite a tailback of heavy goods vehicles there just now, however we would ask the public to be patient with us and to stick by the formal diversion that's on and not to take other routes that they may know if they have local knowledge because that could cause futher disruption."
Police have named a man who died in a crash on the A75 this morning as William Lupton from Creetown.
The 78-year-old from Chain Road was driving a Ford Fiesta car which collided with a Vauxhall Vivaro van and a Citroen Berlingo van on the A75 at Skyreburn in Dumfries and Galloway.
Both of the other drivers, and the passenger in the Citroen, were not seriously injured.
The road is still currently closed as police continue their crash investigation work, and diversions are in place.
Motorists are being told to use the following diversions if they are travelling between Castle Douglas and Newton Stewart.
It follows an earlier crash on the A75 in which one person died and two others were injured.
The A75 is currently closed in both directions between the B796 (Gatehouse Of Fleet) and A755 (Girthon).
- Travelling East: Via A714, A77 and A713 to re-join A75 at Castle Douglas
- Travelling West: Via A713, A77 and A714 to re-join A75 at Newton Stewart
Police in Dumfries and Galloway are warning drivers not to use C class roads to try and shortcut a large diversion following a fatal crash on the A75 at Skyreburn.
Officers say drivers should follow the signposted diversions, which are around 77 miles long.
A force spokesman said: "In particular drivers of heavy goods vehicles should only use the diversion route as other C class roads are not suitable for that type of vehicle."
The A75 is closed in both directions after a fatal crash involving three cars.
Traffic is being diverted between Castle Douglas and Newton Stewart.
The diversion is around 77 miles long.
Police Scotland are currently dealing with a three car road crash on the A75 road at Skyreburn in Dumfries and Galloway. One man has been pronounced dead at the scene and others injured are presently being treated.
The roadway is completely closed and will remain so for some considerable time to allow a full crash scene investigation to take place. Diversions, which are lengthy, are being put in place. Motorists are asked to avoid this area if possible.
Police are renewing their appeal for witnesses after a 19-year-old boy died after being struck by a lorry on the A75 on Saturday night (17th August).
Kieran Currie, and two of his friends, were walking on the eastbound carriageway near to the top the entrance to Calgow farm, about a mile east of Newton Stewart, when he was hit by an eastbound passing lorry.
The lorry did not stop after the collision and has not been traced.
"This is a tragic set of circumstances which has left a young 19-year-old man dead.
"We are appealing to anyone who was using the A75 road in the Newton Stewart area at around 0240 hours on Saturday 17 August 2013 to get in touch with police through 101.
"The lorry which appears to have struck Kieran has yet to be traced, and it may well be that the driver of that vehicle is unaware that he has been in a collision.
"We are appealing for anyone who may have been in the area at that time to get in touch, and in particular, we want to hear from the drivers of all heavy goods vehicles who were on the A75 driving east around that time.
"Likewise we are keen to speak to the occupants of a small blue coloured car who stopped at the scene of the crash shortly after it happened and offered assistance.”